Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia
induced by infarction leads to profound changes in endothelial cell functions and can induce …

A current challenge in genomics is to interpret non-coding regions and their role in transcriptional
regulation of possibly distant target genes. Genome-wide association studies show …

Prediction of transcription factor (TF) binding from epigenetics data and integrative analysis
thereof are challenging. Here, we present TEPIC 2 a framework allowing for fast, accurate …

Mechanisms by which specific histone modifications regulate distinct gene networks remain
little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and …

Circular RNAs are generated by backsplicing and control cellular signaling and phenotypes.
Pericytes stabilize capillary structures and play important roles in the formation and …

Background Eukaryotic gene expression is controlled by cis-regulatory elements (CREs),
including promoters and enhancers, which are bound by transcription factors (TFs). Differential …

Understanding how epigenetic variation in non-coding regions is involved in distal gene-expression
regulation is an important problem. Regulatory regions can be associated to genes …

Non-coding variants located within regulatory elements may alter gene expression by
modifying Transcription Factor (TF) binding sites, thereby leading to functional consequences. …

Background Cardiovascular diseases (CVDs) are the leading cause of death worldwide.
Genome-wide association studies (GWAS) have identified many single nucleotide …

Non-coding variations located within regulatory elements may alter gene expression by
modifying Transcription Factor (TF) binding sites and thereby lead to functional consequences …