Helicobacter pylori specifically colonizes the human gastric epithelium and is the major
causative agent for ulcer disease and gastric cancer development. Here, we identify members of …

Oxidant-mediated antibacterial response systems are broadly used to control bacterial
proliferation. Hypochlorite (HOCl) is an important component of the innate immune system …

Life is resilient because living systems are able to respond to elevated temperatures with an
ancient gene expression program called the heat shock response (HSR). In yeast, the …

Acivicin is a natural product with diverse biological activities. Several decades ago its clinical
application in cancer treatment was explored but failed due to unacceptable toxicity. The …

The colonization of surfaces by bacterial biofilms constitutes a huge problem in healthcare
and industry. When attempting biofilm inactivation or removal, it is crucial to sufficiently wet …

Posttranslational modification (PTM) of proteins represents an important cellular mechanism
for controlling diverse functions such as signalling, localisation or protein–protein …

Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation
of biological amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) …

One‐third of the human proteome is comprised of membrane proteins, which are particularly
vulnerable to misfolding and often require folding assistance by molecular chaperones. …

The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants
a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on …

Cytokines of the interleukin 12 (IL-12) family are assembled combinatorially from shared α
and β subunits. A common theme is that human IL-12 family α subunits remain incompletely …