User profiles for Nina H. Pipalia

Nina Pipalia

Weill Cornell Medical College
Verified email at med.cornell.edu
Cited by 1812

[PDF][PDF] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

TCW Julia, L Qian, NH Pipalia, MJ Chao, SA Liang… - Cell, 2022 - cell.com
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

…, K Chang, S Amin, T Srinivasan, T Zhang, NH Pipalia… - Nature medicine, 2017 - nature.com
With the goal of modeling human disease of the large intestine, we sought to develop an
effective protocol for deriving colonic organoids (COs) from differentiated human embryonic …

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

NH Pipalia, CC Cosner, A Huang… - Proceedings of the …, 2011 - National Acad Sciences
Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1
protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified …

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

J Yao, D Ho, NY Calingasan, NH Pipalia… - Journal of Experimental …, 2012 - rupress.org
There is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer
disease (AD) pathogenesis. Cyclodextrins (CD) are cyclic oligosaccharide compounds …

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele

…, C Davidson, SU Walkley, NH Pipalia… - Journal of …, 2015 - Soc Neuroscience
Niemann-Pick Type C1 (NPC1) disease is a rare neurovisceral, cholesterol–sphingolipid
lysosomal storage disorder characterized by ataxia, motor impairment, progressive intellectual …

STARD4 abundance regulates sterol transport and sensing

B Mesmin, NH Pipalia, FW Lund… - Molecular biology of …, 2011 - Am Soc Cell Biol
Nonvesicular transport of cholesterol plays an essential role in the distribution and regulation
of cholesterol within cells, but it has been difficult to identify the key intracellular cholesterol …

[HTML][HTML] Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells

NH Pipalia, K Subramanian, S Mao, H Ralph… - Journal of lipid …, 2017 - ASBMB
Niemann-Pick C (NPC) disease is an autosomal recessive disorder that leads to excessive
storage of cholesterol and other lipids in late endosomes and lysosomes. The large majority …

[HTML][HTML] Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells

NH Pipalia, A Huang, H Ralph, M Rujoi… - Journal of lipid …, 2006 - ASBMB
Niemann-Pick disease type C (NPC) is an autosomal recessive genetic disorder manifested
by abnormal accumulation of unesterified cholesterol and other lipids. We screened …

Improvement in lipid and protein trafficking in Niemann‐Pick C1 cells by correction of a secondary enzyme defect

C Devlin, NH Pipalia, X Liao, EH Schuchman… - Traffic, 2010 - Wiley Online Library
Different primary lysosomal trafficking defects lead to common alterations in lipid trafficking,
suggesting cooperative interactions among lysosomal lipids. However, cellular analysis of …

Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia

J Tcw, SA Liang, L Qian, NH Pipalia, MJ Chao, Y Shi… - BioRxiv, 2019 - biorxiv.org
Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD).
Although its association with AD is well-established, the impact of APOE ε4 on human brain …