Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence
indicates that miR-143 plays causal roles in cancer tumorigenesis as a tumor suppress …

BACKGROUND Castration‐resistant prostate cancer (CRPC) is a leading cause of cancer‐related
deaths in elder men. This disease has limited therapeutic options and poor prognosis …

Anti-platelet-derived growth factor (PDGF) drugs are routinely used in front-line therapy for
the treatment of various cancers, but the molecular mechanism underlying their dose-…

Background More and more studies have shown that circular RNAs (circRNAs) play a critical
regulatory role in many cancers. However, the potential molecular mechanism of circRNAs …

Interplay between various lymphangiogenic factors in promoting lymphangiogenesis and
lymphatic metastasis remains poorly understood. Here we show that FGF-2 and VEGF-C, two …

Patients with type 2 diabetes (T2D) have decreased butyrate-producing bacteria. We hypothesized
that supplementation with butyrate-producing bacteria may exert beneficial effects on …

The transferability and clinical value of genetic risk scores (GRSs) across populations remain
limited due to an imbalance in genetic studies across ancestrally diverse populations. Here …

Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS,
the most common AIDS-related malignancy. KS is characterized by vast angiogenesis and …