User profiles for Nir Drayman
 | Drayman NirThe University of California, Irvine Verified email at uci.edu Cited by 1366 |
HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations
10.7554/eLife.46339.001 Viral infection is usually studied at the population level by averaging
over millions of cells. However, infection at the single-cell level is highly heterogeneous, …
over millions of cells. However, infection at the single-cell level is highly heterogeneous, …
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …
Virus strategies for passing the nuclear envelope barrier
Viruses that replicate in the nucleus need to pass the nuclear envelope barrier during infection.
Research in recent years indicates that the nuclear envelope is a major hurdle for many …
Research in recent years indicates that the nuclear envelope is a major hurdle for many …
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ongoing
coronavirus disease 2019 (COVID-19) pandemic underscores the need for new treatments. …
coronavirus disease 2019 (COVID-19) pandemic underscores the need for new treatments. …
[PDF][PDF] An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination
…, A Vitenshtein, P Tsukerman, N Drayman… - Cell host & …, 2011 - cell.com
The human polyoma viruses JCV and BKV establish asymptomatic persistent infection in 65%–90%
of humans but can cause severe illness under immunosuppressive conditions. The …
of humans but can cause severe illness under immunosuppressive conditions. The …
[HTML][HTML] A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …
[HTML][HTML] Cannabidiol inhibits SARS-CoV-2 replication and promotes the host innate immune response
The rapid spread of COVID-19 underscores the need for new treatments. Here we report
that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 …
that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 …
[HTML][HTML] High-throughput RNA sequencing of paraformaldehyde-fixed single cells
Single-cell transcriptomic studies that require intracellular protein staining, rare cell sorting,
or inactivation of infectious pathogens are severely limited. This is because current high-…
or inactivation of infectious pathogens are severely limited. This is because current high-…
[HTML][HTML] Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model
The SARS-CoV-2 main viral protease (Mpro) is an attractive target for antivirals given its
distinctiveness from host proteases, essentiality in the viral life cycle and conservation across …
distinctiveness from host proteases, essentiality in the viral life cycle and conservation across …
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest
path to clinical use is repurposing of drugs that have an established safety profile in humans. …
path to clinical use is repurposing of drugs that have an established safety profile in humans. …