User profiles for Niraj K. Nirala
 | Niraj K. NiralaInstructor, Program in Molecular Medicine, University of Massachusetts Chan Medical … Verified email at Umassmed.edu Cited by 404 |
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity
Adenosine triphosphate (ATP) synthase β, the catalytic subunit of mitochondrial complex V,
synthesizes ATP. We show that ATP synthase β is deacetylated by a human nicotinamide …
synthesizes ATP. We show that ATP synthase β is deacetylated by a human nicotinamide …
TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila
Adult stem cells are essential for tissue maintenance and repair. Although genetic pathways
for controlling adult stem cells are extensively investigated in various tissues, much less is …
for controlling adult stem cells are extensively investigated in various tissues, much less is …
[PDF][PDF] Ingestion of food particles regulates the mechanosensing misshapen-yorkie pathway in Drosophila intestinal growth
The intestinal epithelium has a high cell turnover rate and is an excellent system to study
stem cell-mediated adaptive growth. In the Drosophila midgut, the Ste20 kinase Misshapen, …
stem cell-mediated adaptive growth. In the Drosophila midgut, the Ste20 kinase Misshapen, …
Hinfp is a guardian of the somatic genome by repressing transposable elements
Germ cells possess the Piwi-interacting RNA pathway to repress transposable elements
and maintain genome stability across generations. Transposable element mobilization in …
and maintain genome stability across generations. Transposable element mobilization in …
Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors
Internalized membrane proteins are either transported to late endosomes and lysosomes for
degradation or recycled to the plasma membrane. Although proteins involved in trafficking …
degradation or recycled to the plasma membrane. Although proteins involved in trafficking …
[PDF][PDF] The snakeskin-mesh complex of smooth septate junction restricts yorkie to regulate intestinal homeostasis in Drosophila
Tight junctions in mammals and septate junctions in insects are essential for epithelial integrity.
We show here that, in the Drosophila intestine, smooth septate junction proteins provide …
We show here that, in the Drosophila intestine, smooth septate junction proteins provide …
[HTML][HTML] Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis
The sphingolipid ceramide elicits several stress responses, however, organisms survive
despite increased ceramide but how they do so is poorly understood. We demonstrate here that …
despite increased ceramide but how they do so is poorly understood. We demonstrate here that …
[HTML][HTML] dagLogo: An R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data
Sequence logos have been widely used as graphical representations of conserved nucleic
acid and protein motifs. Due to the complexity of the amino acid (AA) alphabet, rich post-…
acid and protein motifs. Due to the complexity of the amino acid (AA) alphabet, rich post-…
Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila
Colorectal cancer is a complex disease driven by well-established mutations such as APC
and other yet to be identified pathways. The GTPase Rab11 regulates endosomal protein …
and other yet to be identified pathways. The GTPase Rab11 regulates endosomal protein …
The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium
The intestinal epithelium has a high rate of cell turn over and is an excellent system to study
stem cell‐mediated tissue homeostasis. The Misshapen subfamily of the Ste20 kinases in …
stem cell‐mediated tissue homeostasis. The Misshapen subfamily of the Ste20 kinases in …