The use of adeno-associated virus (AAV) as a gene therapy vector has been approved
recently for clinical use and has demonstrated efficacy in a growing number of clinical trials. …

Lamination of cortical regions of the vertebrate brain depends on glial-guided neuronal
migration. The conserved polarity protein Par6α localizes to the centrosome and coordinates …

Recent experiments show that the microtubule-associated protein (MAP) 1B is a major
phosphorylation substrate for the serine/threonine kinase glycogen synthase kinase-3β (GSK-3β) …

Isolated methylmalonic acidemia (MMA), caused by deficiency of the mitochondrial enzyme
methylmalonyl-CoA mutase (MUT), is often complicated by end stage renal disease that is …

Alternative splicing ( AS ) is a key regulatory mechanism for the development of different
tissues; however, not much is known about changes to alternative splicing during aging. …

The brain’s circuitry is established by directed migration and synaptogenesis of neurons
during development. Although neurons mature and migrate in specific patterns, little is known …

10.7554/eLife.12717.001 In the developing mammalian brain, differentiating neurons mature
morphologically via neuronal polarity programs. Despite discovery of polarity pathways …

Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an
autosomal dominant disease of the hematopoietic system that is caused by heterozygous …

Alcohol abuse is a common human disorder with high rate of comorbidity with other psychiatric
disorders. To identify candidate mechanisms for alcohol abuse, the expression of 12,626 …

We have developed a novel pulse-escape fluorescence photoactivation technique to
investigate the long-term pausing behavior of axonal neurofilaments. Cultured sympathetic …