Gene silencing through RNA interference (RNAi) has revolutionized the study of gene function,
particularly in non-model insects. However, in Lepidoptera (moths and butterflies) RNAi …

Acetylcholinesterase (AChE) is a critical enzyme, in Alzheimer's disease (AD) progression
and hence has been subjected to intense drug discovery programme. Here, we report …

Gene duplication is a characteristic feature of eukaryotic genomes. Here we investigated
the role of gene duplication in the evolution of the gloverin family of antibacterial genes (Bmglv1…

Many proteins of the Rel family can act as both transcriptional activators and repressors.
However, mechanism that discerns the ‘activator/repressor’ functions of Rel-proteins such as …

Understanding adaptations to climatic stresses has been a longstanding issue in evolutionary
biology. Clinal patterns for stress tolerance traits at interspecific as well as intraspecific …

Autoregulation is one of the mechanisms of imparting feedback control on gene expression.
Positive autoregulatory feedback results in induction of a gene, and negative feedback …

With the rapid emergence of drug resistant pathogens, it has become imperative to develop
alternative medications as well as find new drug targets to overcome this crisis. Hence, this …

Transcription factors (TFs) bind at multiple sites in the genome and regulate expression of
many genes. Regulating TF binding in a gene specific manner remains a formidable …

Toll proteins play roles in immunity/development which have largely remained conserved.
However, there are differences in Toll biology as mammalian TLRs recognise pathogen …

The identification of the Toll receptor in Drosophila was a major discovery which restructured
the paradigm in immunity as well as developmental biology. Toll homologues are present …