The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical protein
kinase C (aPKC) form a core unit of the PAR protein network, which plays a central role in …

How do cells polarize at the correct time and in response to the correct cues? In the C. elegans
zygote, the timing and geometry of polarization rely on a single dominant cue—the sperm …

Reaction–diffusion networks underlie pattern formation in a range of biological contexts,
from morphogenesis of organisms to the polarization of individual cells. One requirement for …

Clustering of membrane-associated molecules is thought to promote interactions with the
actomyosin cortex, enabling sizedependent transport by actin flows. Consistent with this model…

During development, the conserved PAR polarity network is continuously redeployed,
requiring that it adapt to changing cellular contexts and environmental cues. In the early C. …

Biological systems are increasingly viewed through a quantitative lens that demands
accurate measures of gene expression and local protein concentrations. CRISPR/Cas9 gene …

The association of molecules within membrane microdomains is critical for the intracellular
organization of cells. During polarization of the C. elegans zygote, both polarity proteins and …

A key challenge in the development of an organism is to maintain robust phenotypic outcomes
in the face of perturbation. Yet, how such robust outcomes are encoded by developmental …

Studies in Caenorhabditiselegans have revealed osmoregulatory systems engaged when
worms experience hypertonic conditions, but less is known about measures employed when …

During development, the conserved PAR polarity network is continuously redeployed, requiring
that it adapts to changing cellular contexts and environmental cues. How it does so and …