Overcoming metabolic stress is a critical step for solid tumour growth 1 , 2 . However, the
underlying mechanisms of cell death and survival under metabolic stress are not well …

Serum and certain growth factors have the ability to inhibit programmed cell death (apoptosis)
and promote survival. The mechanism by which growth factors deliver an anti-apoptotic …

FoxO transcription factors and TORC1 are conserved downstream effectors of Akt. Here, we
unraveled regulatory circuits underlying the interplay between Akt, FoxO, and mTOR. …

FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt
and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits …

The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has
emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis…

The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed
step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major …

The serine/threonine kinase Akt has been implicated in the control of cell survival and
metabolism. Here we report the disruption of the most ubiquitously expressed member of theakt …

The serine/threonine kinase Akt/PKB is a major downstream effector of growth factor–mediated
cell survival. Activated Akt, like Bcl-2 and Bcl-xL, prevents closure of a PT pore …

Growth factors and hormones activate protein translation by phosphorylation and inactivation
of the translational repressors, the eIF4E-binding proteins (4E-BPs), through a wortmannin- …

The serine/threonine kinase Akt, or protein kinase B (PKB), has recently been a focus of
intense research. It appears that Akt/PKB lies in the crossroads of multiple cellular signaling …