SMARCAD1-mediated active replication fork stability maintains genome integrity
The stalled fork protection pathway mediated by breast cancer 1/2 (BRCA1/2) proteins is
critical for replication fork stability. However, it is unclear whether additional mechanisms are …
critical for replication fork stability. However, it is unclear whether additional mechanisms are …
Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe
Eukaryotic genomes are folded into three-dimensional structures, such as self-associating
topological domains, the borders of which are enriched in cohesin and CCCTC-binding factor …
topological domains, the borders of which are enriched in cohesin and CCCTC-binding factor …
Spreading and epigenetic inheritance of heterochromatin require a critical density of histone H3 lysine 9 tri-methylation
AR Cutter DiPiazza, N Taneja… - Proceedings of the …, 2021 - National Acad Sciences
Heterochromatin assembly requires methylation of histone H3 lysine 9 (H3K9me) and serves
as a paradigm for understanding the importance of histone modifications in epigenetic …
as a paradigm for understanding the importance of histone modifications in epigenetic …
[HTML][HTML] Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance
…, V Balachandran, J Dhakshnamoorthy, N Taneja… - Cell, 2013 - cell.com
The regulation of protein-coding and noncoding RNAs is linked to nuclear processes, including
chromatin modifications and gene silencing. However, the mechanisms that distinguish …
chromatin modifications and gene silencing. However, the mechanisms that distinguish …
[HTML][HTML] Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …
the process of epigenetic reorganization and its implication for fork stability is poorly …
Different SWI/SNF complexes coordinately promote R-loop-and RAD52-dependent transcription-coupled homologous recombination
The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF, …
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF, …
[PDF][PDF] SNF2 family protein Fft3 suppresses nucleosome turnover to promote epigenetic inheritance and proper replication
N Taneja, M Zofall, V Balachandran, G Thillainadesan… - Molecular cell, 2017 - cell.com
Heterochromatin can be epigenetically inherited in cis, leading to stable gene silencing.
However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we …
However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we …
[HTML][HTML] R-Loops and its chro-Mates: the strange case of Dr. Jekyll and Mr. Hyde
Since their discovery, R-loops have been associated with both physiological and pathological
functions that are conserved across species. R-loops are a source of replication stress …
functions that are conserved across species. R-loops are a source of replication stress …
Shelterin components mediate genome reorganization in response to replication stress
T Mizuguchi, N Taneja, E Matsuda… - Proceedings of the …, 2017 - National Acad Sciences
The dynamic nature of genome organization impacts critical nuclear functions including the
regulation of gene expression, replication, and DNA damage repair. Despite significant …
regulation of gene expression, replication, and DNA damage repair. Despite significant …
A microfluidic cancer-on-chip platform predicts drug response using organotypic tumor slice culture
The Cancer-on-Chip platform with a 6-well plate design incorporating silicon-based
microfluidics can enable optimal patient-specific treatment strategies through parallel culture of …
microfluidics can enable optimal patient-specific treatment strategies through parallel culture of …