Background Symptomatic malaria cases reflect only a small proportion of all Plasmodium
spp infections. Many infected individuals are asymptomatic, and persistent asymptomatic …

The growing prevalence of deadly microbes with resistance to previously life-saving drug
therapies is a dire threat to human health. Detection of low abundance pathogen sequences …

Predicting the function of noncoding variation is a major challenge in modern genetics. In
this study, we used massively parallel reporter assays to screen 5706 variants identified from …

Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection
in males compared to females. To test the hypothesis that sex-based differences in host-…

Background Targeted next-generation sequencing offers the potential for consistent, deep
coverage of information-rich genomic regions to characterize polyclonal Plasmodium …

Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites
during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. …

Protection against Plasmodium falciparum, which is primarily antibody-mediated, requires
recurrent exposure to develop. The study of both naturally acquired limited immunity and …

Background Whole-genome sequencing (WGS) is becoming increasingly useful to study the
biology, epidemiology, and ecology of malaria parasites. Despite ease of sampling, DNA …

Protection against Plasmodium falciparum, which is primarily antibody-mediated, requires
recurrent exposure to develop. The study of both naturally acquired limited immunity and …

Multiplexed genetic perturbations are critical for testing functional interactions among coding
or non-coding genetic elements. Compared to double-stranded DNA cutting, repressive …