The effectiveness of chimeric Ag receptor (CAR)–transduced T (CAR-T) cells has been
attributed to supraphysiological signaling through CARs. Second-and later-generation CARs …

Immune checkpoint therapy has resulted in remarkable improvements in the outcome for
certain cancers. To broaden the clinical impact of checkpoint targeting, we devised a strategy …

Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because glioblastoma
stem cells (GSCs) are resistant to all standard therapies. We showed that GSCs, but not …

Ibrutinib, a covalent inhibitor of Bruton Tyrosine Kinase (BTK), is approved for treatment of
patients with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). …

ORF8 is an accessory protein encoded by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Consensus regarding the biological functions of ORF8 is lacking, largely …

The ability of cord blood transplantation (CBT) to prevent relapse depends partly on donor
natural killer (NK) cell alloreactivity. NK effector function depends on specific killer-cell …

We retrospectively reviewed 104 biopsy specimens of previously untreated skin acute graft-versus-host
disease (GVHD) within 100 days after allogeneic stem cell transplantation, and …

Regulatory T cells (Tregs) play a fundamental role in the maintenance of self-tolerance and
immune homeostasis. Defects in Treg function and/or frequencies have been reported in …

Natural killer (NK) cells are highly heterogeneous, with vast phenotypic and functional
diversity at the single-cell level. They are involved in the innate immune response against …

Macrophage infiltration of skin GVHD lesions correlates directly with disease severity, but
the mechanisms underlying this relationship remain unclear and GVHD with many …