Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available.
Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h, containing …

Introduction Recent accumulating evidence indicates a crucial involvement of macrophage
lineage in the pathogenesis of systemic sclerosis (SSc). To analyze the assembly of the …

Here, we report the synthesis, structure–activity relationship studies, enzyme inhibition,
antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate …

COVID-19 caused by SARS-CoV-2 has continually been serious threat to public health
worldwide. While a few anti-SARS-CoV-2 therapeutics are currently available, their antiviral …

Localized scleroderma is a connective tissue disorder that is limited to the skin and subcutaneous
tissue. Macrophages have been reported to be particularly activated in patients with …

The main protease (M pro ) of SARS-CoV-2 is an attractive target for the development of
drugs to treat COVID-19. Here, we report the design, synthesis, and structure–activity …

Potent and biostable inhibitors of the main protease (M pro ) of SARS-CoV-2 were designed
and synthesized based on an active hit compound 5h (2). Our strategy was based not only …

Certain nucleoside/nucleotide reverse transcriptase (RT) inhibitors (NRTIs) are effective
against human immunodeficiency virus type 1 (HIV‐1) and hepatitis B virus (HBV). However, …

10.7554/eLife.28020.001 Antiretroviral therapy for HIV-1 infection/AIDS has significantly
extended the life expectancy of HIV-1-infected individuals and reduced HIV-1 transmission at …

Despite various attempts to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected
patients with COVID-19 convalescent plasmas, neither appropriate approach …