User profiles for Noe B. Mercado

Noe B. Mercado

Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown …
Verified email at brown.edu
Cited by 7813

[HTML][HTML] Potently neutralizing and protective human antibodies against SARS-CoV-2

…, BK Mueller, J Meiler, A Chandrashekar, NB Mercado… - Nature, 2020 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

J Yu, LH Tostanoski, L Peter, NB Mercado, K McMahan… - Science, 2020 - science.org
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top …

[HTML][HTML] Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

NB Mercado, R Zahn, F Wegmann, C Loos… - Nature, 2020 - nature.com
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
may be required to end the coronavirus disease 2019 (COVID-19) pandemic 1 , 2 , 3 , 4 …

[HTML][HTML] Correlates of protection against SARS-CoV-2 in rhesus macaques

K McMahan, J Yu, NB Mercado, C Loos, LH Tostanoski… - Nature, 2021 - nature.com
Recent studies have reported the protective efficacy of both natural 1 and vaccine-induced
2 , 3 , 4 , 5 , 6 – 7 immunity against challenge with severe acute respiratory syndrome …

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

…, J Liu, AJ Martinot, K McMahan, NB Mercado… - Science, 2020 - science.org
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global …

[HTML][HTML] Vaccine protection against Zika virus from Brazil

…, D Ng'ang'a, M Kirilova, R Nityanandam, NB Mercado… - Nature, 2016 - nature.com
Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the
Americas 1 , 2 . ZIKV has been causally associated with fetal microcephaly, intrauterine …

Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

…, O Nanayakkara, R Nityanandam, NB Mercado… - Science, 2016 - science.org
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been
causally associated with fetal microcephaly. The development of a safe and effective ZIKV …

[HTML][HTML] Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

…, AJ Martinot, C Loos, K McMahan, NB Mercado… - Nature medicine, 2020 - nature.com
Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some
individuals develop severe pneumonia, respiratory failure and death 1 , 2 , 3 – 4 . Studies of …

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

…, WH Yu, S Fischinger, T Broge, P Abbink, NB Mercado… - Nature, 2018 - nature.com
The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection.
Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly …

[HTML][HTML] Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

…, N Roth, J Yu, A Chandrashekar, NB Mercado… - Nature, 2022 - nature.com
The CVnCoV (CureVac) mRNA vaccine for severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) was recently evaluated in a phase 2b/3 efficacy trial in humans 1 . CV2CoV …