Genome-wide association studies have identified many noncoding variants associated with
common diseases and traits. We show that these variants are concentrated in regulatory …

The QRS interval, from the beginning of the Q wave to the end of the S wave on an
electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for …

Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease
Control and Prevention, the National Institutes of Health, and other government agencies, …

Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease
Control and Prevention, the National Institutes of Health, and other government agencies, …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Background Tools for the prediction of atrial fibrillation ( AF ) may identify high‐risk individuals
more likely to benefit from preventive interventions and serve as a benchmark to test novel …

Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 US …

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure
and death 1 . We conducted a genome-wide association study (GWAS) in individuals of …

QT interval duration, reflecting myocardial repolarization on the electrocardiogram, is a
heritable risk factor for sudden cardiac death and drug-induced arrhythmias. We conducted a …