Proper spatiotemporal gene expression is achieved by selective DNA binding of transcription
factors in the genome. The most intriguing question is how dynamic interactions between …

Transcriptional regulation is crucial for neuronal activity-dependent processes that govern
neuronal circuit formation and synaptic plasticity. An intriguing question is how neuronal …

Transcriptional regulation of gene expression is thought to play a pivotal role in activity‐dependent
neuronal differentiation and circuit formation. Here, we investigated the role of …

DNA polymerase β (Polβ) has been implicated in base excision repair in mammalian cells.
However, the physiological significance of this enzyme in the body remains unclear. Here, we …

Genome stability is essential for brain development and function, as de novo mutations
during neuronal development cause psychiatric disorders. However, the contribution of DNA …

During development, cortical neurons extend axons to their targets based on their laminar
locations and cell types. Here we studied the molecular mechanism that regulates medially …

DNA repair is crucial for genome stability in the developing cortex, as somatic de novo
mutations cause neurological disorders. However, how DNA repair contributes to neuronal …

Although heat shock proteins (HSP) are well known to contribute to thermotolerance, they
only play a supporting role in the phenomenon. Recently, it has been reported that heat …

Neuronal activity-dependent transcription plays a key role in plasticity and pathology in the
brain. An intriguing question is how neuronal activity controls gene expression via …

Axon branching and synapse formation are critical processes for establishing precise circuit
connectivity. These processes are tightly regulated by neural activity, but the relationship …