Glypicans are a family of heparan sulfate proteoglycans that are linked to the cell surface
through a glycosyl–phosphatidylinositol anchor. One member of this family, glypican-3 (Gpc3), …

Idiopathic antenatal hydronephrosis (IAHN), defined as antenatal hydronephrosis not
associated with other morphologic renal tract abnormalities, is the most common abnormality …

To elucidate the molecular pathways that modulate renal cyst growth in ADPKD, we performed
global gene profiling on cysts of different size (<1 ml, n = 5; 10–20 ml, n = 5; >50 ml, n = 3) …

Abnormalities of kidney and urinary tract development are the most common cause of end-stage
kidney failure in childhood in the United States. Over the past 20 years, the advent of …

Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of autosomal
dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage resulting in the …

Truncating mutations in Gli3, an intracellular effector in the SHH-SMO-GLI signaling pathway,
cause renal aplasia/dysplasia in humans and mice. Yet, the pathogenic mechanisms are …

The kidney of the Gpc3−/ mouse, a novel model of human renal dysplasia, is characterized
by selective degeneration of medullary collecting ducts preceded by enhanced cell …

WNT/β-catenin signaling has an established role in nephron formation during kidney
development. Yet, the role of β-catenin during ureteric morphogenesis in vivo is undefined. We …

Henoch-Schonlein purpura is a systemic vasculitis of unknown cause that is characterized
primarily by abdominal pain, arthritis, and purpuric skin lesions. Abdominal pain is the most …

Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced
nephron number, is a common cause of pediatric renal failure and adult-onset disease. …