RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …

Most proteins fold into 3D structures that determine how they function and orchestrate the
biological processes of the cell. Recent developments in computational methods for protein …

Traditionally, protein–protein interactions were thought to be mediated by large, structured
domains. However, it has become clear that the interactome comprises a wide range of …

A molecular description of functional modules in the cell is the focus of many high-throughput
studies in the postgenomic era. A large portion of biomolecular interactions in virtually all …

Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource
remains an invaluable source of information for the study of motif-mediated protein-protein …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to mediate
the functions required for cell viability. Specific, context-dependent and tightly controlled …

Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …

The eukaryotic linear motif (ELM http://elm.eu.org ) resource is a hub for collecting, classifying
and curating information about short linear motifs (SLiMs). For >10 years, this resource has …

Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide
low-affinity interaction interfaces. These compact modules play central roles in mediating …

The Database of Protein Disorder (DisProt, URL: www.disprot.org ) has been significantly
updated and upgraded since its last major renewal in 2007. The current release holds …