Rolling back malaria is possible. Tools are available but they are not used. Several countries
deploy, as their national malaria control treatment policy, drugs that are no longer effective. …

Background Chloroquine is the first-line treatment for Plasmodium vivax malaria in most
endemic countries, but resistance is increasing. Monitoring of antimalarial efficacy is essential, …

In prospective studies of acute uncomplicated, multidrug-resistant falciparum malaria on the
western border of Thailand, the oral artemisinin derivatives were used alone in the treatment …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia
and now poses a threat to the control and elimination of malaria. Mapping the geographic …

Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted
class of antimalarials—have prompted a need for new treatments. The spirotetrahydro-β-…

Multilocus genotyping of microbial pathogens has revealed a range of population structures,
with some bacteria showing extensive recombination and others showing almost complete …

Background On the western border of Thailand the efficacy of mefloquine in the treatment of
falciparum malaria has declined while gametocyte carriage rates have increased, which …

We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, …

Background . Malaria in humans is caused by apicomplexan parasites belonging to 5 species
of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …