Major depression and anxiety disorders are a social and economic burden worldwide.
Serotonergic signaling has been implicated in the pathophysiology of these disorders and thus …

Several lines of evidence indicate that ketamine has a rapid antidepressant-like effect in
rodents and humans, but underlying mechanisms are unclear. In the present study, we …

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by the
repeated rise of concerns (obsessions) and repetitive unwanted behavior (compulsions). …

Perseveration is a characteristic of patients with obsessive–compulsive disorder (OCD).
Clinically, neuronal activity in the lateral orbitofrontal cortex (OFC) is increased in OCD patients. …

Background Ketamine rapidly elicits antidepressive effects in humans and mice in which
serotonergic activity is involved. Although α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) …

The involvement of reactive oxygen species (ROS) has been suggested in the development
of inflammatory bowel disease (IBD). An impaired intestinal barrier function is common in …

Repetitive behavior is a widely observed neuropsychiatric symptom. Abnormal dopaminergic
signaling in the striatum is one of the factors associated with behavioral repetition; however…

Obsessive-compulsive disorder (OCD) is a highly prevalent neuropsychiatric disorder
poorly controlled with pharmacological treatment because of the wide variation in symptom …

Antipsychotics often cause tardive dyskinesia, an adverse symptom of involuntary hyperkinetic
movements. Analysis of the US Food and Drug Administration Adverse Event Reporting …

Clioquinol (5-chloro-7-indo-8-quinolinol), a chelator and ionophore of copper/zinc, was
extensively used as an amebicide to treat indigestion and diarrhea in the mid-1900s. However, it …