Signaling through the T cell receptor (TCR) controls adaptive immune responses. Antigen
binding to TCRαβ transmits signals through the plasma membrane to induce phosphorylation …

10.7554/eLife.42475.001 The immune system distinguishes between self and foreign antigens.
The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign …

Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic
tails by the tyrosine kinase Lck. How Lck is recruited to the TCR to initiate signaling is …

The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting
T cell antigen receptor triggering to downstream T cell responses. In this study, we describe …

Methodologies for the controlled delivery of genetic information into target cells are of utmost
importance for genetic engineering in both fundamental and applied research. However, …

Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the
αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is …

Optogenetic approaches have gathered momentum in precisely modulating and interrogating
cellular signalling and gene expression. The use of optogenetics on the outer cell surface …

The kinetics of a ligand-receptor interaction determine the responses of the receptor-expressing
cell. One approach to experimentally and reversibly change this kinetics on demand is …

Ligand binding to the TCR causes a conformational change at the CD3 subunits to expose
the CD3ε cytoplasmic proline-rich sequence (PRS). It was suggested that the PRS is …

Optogenetics is a versatile and powerful tool for the control and analysis of cellular signaling
processes. The activation of cellular receptors by light using optogenetic switches usually …