A guide to genetically encoded tools for the study of H2O2

DD Smolyarova, OV Podgorny, DS Bilan… - The FEBS …, 2022 - Wiley Online Library
Cell metabolism heavily relies on the redox reactions that inevitably generate reactive
oxygen species (ROS). It is now well established that ROS fluctuations near basal levels …

[HTML][HTML] In vivo imaging with genetically encoded redox biosensors

…, DA Kotova, DI Maltsev, OV Podgorny… - International journal of …, 2020 - mdpi.com
Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

[HTML][HTML] Recent advances in nucleotide analogue-based techniques for tracking dividing stem cells: An overview

…, DI Maltsev, VV Belousov, OV Podgorny - Journal of Biological …, 2021 - ASBMB
Detection of thymidine analogues after their incorporation into replicating DNA represents a
powerful tool for the study of cellular DNA synthesis, progression through the cell cycle, cell …

[HTML][HTML] Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity

…, VA Shaydurov, AV Rozov, OV Podgorny… - Redox biology, 2023 - Elsevier
Oxidative stress, a state of disrupted redox signaling, reactive oxygen species (ROS)
overproduction, and oxidative cell damage, accompanies numerous brain pathologies, including …

Glucocorticoid‐mediated mechanisms of hippocampal damage: Contribution of subgranular neurogenesis

OV Podgorny, NV Gulyaeva - Journal of Neurochemistry, 2021 - Wiley Online Library
A comprehensive overview of the interplay between glucocorticoids (GCs) and adult hippocampal
neurogenesis (AHN) is presented, particularly, in the context of a diseased brain. The …

[HTML][HTML] Novel genetically encoded bright positive calcium indicator NCaMP7 based on the mNeonGreen fluorescent protein

…, AM Varizhuk, GE Pozmogova, OV Podgorny… - International journal of …, 2020 - mdpi.com
Green fluorescent genetically encoded calcium indicators (GECIs) are the most popular tool
for visualization of calcium dynamics in vivo. However, most of them are based on the EGFP …

[HTML][HTML] Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

VV Babenko, OV Podgorny, VA Manuvera… - BMC genomics, 2020 - Springer
Background Salivary cell secretion (SCS) plays a critical role in blood feeding by medicinal
leeches, making them of use for certain medical purposes even today. Results We annotated …

Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens

…, IA Talyzina, NF Polina, OV Podgorny… - European Journal of …, 2019 - Elsevier
The rise of antibiotic resistance has necessitated the development of alternative strategies
for the treatment of infectious diseases. Antimicrobial peptides (AMPs), components of the …

Laser microdissection: A promising tool for exploring microorganisms and their interactions with hosts

OV Podgorny, VN Lazarev - Journal of microbiological methods, 2017 - Elsevier
Laser microdissection is a method that allows for the isolation of homogenous cell populations
from their native niches in tissues for downstream molecular assays. This method is …

[HTML][HTML] Detection of de novo dividing stem cells in situ through double nucleotide analogue labeling

S Itaman, G Enikolopov, OV Podgorny - Cells, 2022 - mdpi.com
Tissue-specific somatic stem cells are characterized by their ability to reside in a state of
prolonged reversible cell cycle arrest, referred to as quiescence. Maintenance of a balance …