Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their biogenesis
and possible functions are poorly understood. Here, by studying circRNAs that we …

Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their
abundance, their function and expression in the nervous system are unknown. Therefore, we …

Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely
unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing …

Although clonal neo-antigen burden is associated with improved response to immune
therapy, the functional basis for this remains unclear. Here we study this question in a novel …

BACKGROUND. The circadian clock is a fundamental and pervasive biological program that
coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to …

Extensive tumour inflammation, which is reflected by high levels of infiltrating T cells and
interferon-γ (IFNγ) signalling, improves the response of patients with melanoma to checkpoint …

… By generating fly lines to specifically modulate the levels of all mbl RNA isoforms, including
circMbl, we demonstrate that the two major mbl protein isoforms, MBL-O/P and MBL-C, buffer …

Circadian (24 h) clocks provide a source of internal timing in most living organisms. These
clocks keep time by using complex transcriptional/post-translational feedback loops that are …

Circadian rhythms are generated by the cyclic transcription, translation, and degradation of
clock gene products, including timeless (tim), but how the circadian clock senses and adapts …

Research background: Online shopping is becoming popular among most customers thanks
to quickness and easy shopping, and also due the COVID pandemic. Companies are …