[HTML][HTML] Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
…, K Boyd, DM Grijseels, D Clarke, O Bonnar… - Nature …, 2021 - nature.com
… 27 , we used these estimates of interRBC [O 2 ] as the capillary [O 2 ] in our model. Indeed if
… [O 2 ], tissue [O 2 ] estimates were impossibly much higher than the expected interRBC [O 2 ] …
… [O 2 ], tissue [O 2 ] estimates were impossibly much higher than the expected interRBC [O 2 ] …
A multi‐hit hypothesis for an APOE4‐dependent pathophysiological state
…, L Minkley, K Shaw, O Bonnar… - European Journal of …, 2022 - Wiley Online Library
The APOE gene encoding the Apolipoprotein E protein is the single most significant genetic
risk factor for late‐onset Alzheimer's disease. The APOE4 genotype confers a significantly …
risk factor for late‐onset Alzheimer's disease. The APOE4 genotype confers a significantly …
Spontaneous vasomotion propagates along pial arterioles in the awake mouse brain like stimulus-evoked vascular reactivity
LP Munting, O Bonnar, MG Kozberg… - Journal of Cerebral …, 2023 - journals.sagepub.com
Sensory stimulation evokes a local, vasodilation-mediated blood flow increase to the activated
brain region, which is referred to as functional hyperemia. Spontaneous vasomotion is a …
brain region, which is referred to as functional hyperemia. Spontaneous vasomotion is a …
[HTML][HTML] Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of …
RN Taddei, MV Sanchez-Mico, O Bonnar… - Acta Neuropathologica …, 2022 - Springer
Clinico-pathological correlation studies show that some otherwise healthy elderly individuals
who never developed cognitive impairment harbor a burden of Alzheimer’s disease lesions …
who never developed cognitive impairment harbor a burden of Alzheimer’s disease lesions …
[HTML][HTML] Gradual not sudden change: multiple sites of functional transition across the microvascular bed
…, M Hammond-Haley, D Amin, O Bonnar… - Frontiers in Aging …, 2022 - frontiersin.org
In understanding the role of the neurovascular unit as both a biomarker and target for disease
interventions, it is vital to appreciate how the function of different components of this unit …
interventions, it is vital to appreciate how the function of different components of this unit …
Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences
…, L Bell, K Boyd, DM Grijseels, D Clarke, O Bonnar… - BioRxiv, 2019 - biorxiv.org
… capillary spacing in HC reduce tissue [O 2 ], limiting oxidative … to rate-limiting [O 2 ] by
calculating profiles for [O 2 ] and VO 2 … This analysis suggested that low [O 2 ] inhibits VO 2 by at …
calculating profiles for [O 2 ] and VO 2 … This analysis suggested that low [O 2 ] inhibits VO 2 by at …
APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice
Vascular factors are known to be early and important players in Alzheimer’s disease (AD)
development, however the role of the ε4 allele of the Apolipoprotein (APOE) gene (a risk factor …
development, however the role of the ε4 allele of the Apolipoprotein (APOE) gene (a risk factor …
First, tau causes NO problem
O Bonnar, CN Hall - Nature Neuroscience, 2020 - nature.com
Pathological tau disrupts the association between nitric oxide (NO) synthase and PSD95,
impairing NO signaling and neurovascular coupling before causing neurodegeneration. …
impairing NO signaling and neurovascular coupling before causing neurodegeneration. …
The MTS assay as an indicator of chemosensitivity/resistance in malignant gynaecological tumours
…, NC Gleeson, M Yoneda, J Bonnar - Cancer detection and …, 2003 - Elsevier
The aim of this study was to use the (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium,
inner salt) (MTS) assay to determine the response of 17 …
inner salt) (MTS) assay to determine the response of 17 …
A template for defining a causal relationship between acute intrapartum events and cerebral palsy
…, M Bennett, E Blair, J Bonnar… - Australian and …, 2000 - research-repository.uwa.edu.au
A template for defining a causal relationship between acute intrapartum events and cerebral
palsy — the UWA Profiles and Research Repository Skip to main navigation Skip to search …
palsy — the UWA Profiles and Research Repository Skip to main navigation Skip to search …