An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal
dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is …

The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share
marked structural and functional similarities with ours, providing attractive models to dissect …

Background Dietary restriction (DR), a reduction in food intake without malnutrition, increases
most aspects of health during aging and extends lifespan in diverse species, including …

… After mixing for 30 min, H 2 O (0.12 ml) was added followed by vortexing. After the addition
of 0.3 ml chloroform and 0.3 ml H 2 O, the sample was mixed again for 10 min, and phase …

In insects and vertebrates alike, hearing is assisted by the motility of mechanosensory cells.
Much like pushing a swing augments its swing, this cellular motility is thought to actively …

Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of
life of older people. Strikingly similar declines in sleep quality are seen during ageing in …

Unconventional myosins have been associated with hearing loss in humans, mice, and
zebrafish. Mutations in myosin VI cause both recessive and dominant forms of nonsyndromic …

The decision to move towards a mating partner or a food source is essential for life. The
mechanisms underlying these behaviors are not well understood. Here, we investigated the role …

G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo …

Restriction of amino acids in the diet can extend lifespan in diverse species ranging from
flies to mammals. However, the role of individual amino acids and the underlying molecular …