Most of the excitatory synapses on principal neurons of the forebrain are located on
specialized structures called dendritic spines. Their morphology, comprising a spine head …

The brain adaptively integrates present sensory input, past experience, and options for future
action. The insect mushroom body exemplifies how a central brain structure brings about …

The local synthesis of transmembrane proteins underlies functional specialization of dendritic
microdomains in neuronal plasticity. It is unclear whether these proteins have access to …

… Briefly, proteins were isolated using 400 μl lysis buffer (2 × PI w/o extra EDTA) provided in the
… 2 S 2 O 5 5H 2 O, AppliChem) and 15 mM potassium cyanoferrate (C 6 FeK 3 N 6 , Sigma). …

… In addition, treatment of the slices with JPK partially rescued the shift in the I/O curve (Figure
8B). Since the synaptic phenotype in caldendrin-knockout mice indicates the absence …

… n = 59 (shafts associated w/o homer1), n = 101 (shaft associated w homer1), n = 40 (spine
associated w/o homer1), and n = 38 (spine associated w homer1) patches from 27 analyzed …

Two key proteins for cellular communication between astrocytes and neurons are αvβ3
integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent (trans…

KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) K + channels dampen neuronal excitability and their
functional impairment may lead to epilepsy. Less is known about KCNQ5 (Kv7.5), which also …

Sustained fast neurotransmission requires the rapid replenishment of release-ready synaptic
vesicles (SVs) at presynaptic active zones. Although the machineries for exocytic fusion …

… (O–Q) In mosaic Ca v 2 null mutants generated with the FLP-stop method, PSC amplitude
is reduced by >90% at Ca v 2 knock out synapses (red traces) but normal at control NMJs (…