Despite broad scientific interest in harnessing the power of Earth’s microbiomes, knowledge
gaps hinder their efficient use for addressing urgent societal and environmental challenges. …

Microbiomes are complex and ubiquitous networks of microorganisms whose seemingly
limitless chemical transformations could be harnessed to benefit agriculture, medicine, and …

Highlights • Dynamic models are powerful tools to understand and engineer microbial
communities. • Model frameworks vary across scales and require different types of experimental …

The ecological forces that govern the assembly and stability of the human gut microbiota
remain unresolved. We developed a generalizable model‐guided framework to predict higher‐…

The capability to design microbiomes with predictable functions would enable new technologies
for applications in health, agriculture, and bioprocessing. Towards this goal, we develop …

FoxO transcription factors have a conserved role in longevity, and act as tissue-specific tumor
suppressors in mammals. Several nodes of interaction have been identified between FoxO …

… of cells (arrow highlights that increasing N o decreases the duration of bimodality—δ g ). (C)
The relationship between the values of N o and δ g for three concentrations of glucose. (D) …

Polysaccharide utilization loci (PULs) are co-regulated bacterial genes that sense nutrients
and enable glycan digestion. Human gut microbiome members, notably Bacteroides, contain …

… The difference between <ν> ∞ and <ν> o is a measure of the extent to which some P450
neutral network nodes have more connections than others. We note that <ν> ∞ is …

Microbial interactions are major drivers of microbial community dynamics and functions but
remain challenging to identify because of limitations in parallel culturing and absolute …