Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …

Studies that elucidate why some human tissues age faster than others may shed light on
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …

DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …

By analyzing multitissue gene expression and genome-wide genetic variation data in samples
from a vervet monkey pedigree, we generated a transcriptome resource and produced …

Maximum lifespan of a species is the oldest that individuals can survive, reflecting the genetic
limit of longevity in an ideal environment. Here we report methylation-based models that …

… Oi-Wa Choi … Saarela J, Kallio SP, Chen D, Montpetit A, Jokiaho A, Choi E, Asselta R,
Bronnikov D, Lincoln MR, Sadovnick AD, et al: PRKCA and multiple sclerosis: association in …

We reported previously a significant linkage signal between psychotic bipolar disorder (BP)
and microsatellite markers on chromosome 5q31–34 in the National Institute of Mental …