The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation
has devastating consequences, including cancer 1 , 2 – 3 . The cell cycle is driven by …

The production and maintenance of genetic and phenotypic diversity under temporally
fluctuating selection and the signatures of environmental changes in the patterns of this variation …

Aging is associated with widespread changes in genome-wide patterns of DNA methylation.
Thousands of CpG sites whose tissue-specific methylation levels are strongly correlated …

Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of
within-host diversification is less understood. Here we develop a novel computational tool (…

Phenotypic plasticity is an evolutionary driving force in diverse biological processes, including
the adaptive immune system, the development of neoplasms, and the persistence of …

DNA methylation is an epigenetic modification, influenced by both genetic and environmental
variation, that plays a key role in transcriptional regulation and many organismal …

Background Using high-throughput sequencing to monitor translation in vivo, ribosome profiling
can provide critical insights into the dynamics and regulation of protein synthesis in a cell…

Environmental variation is commonplace, but unpredictable. Populations that encounter a
deleterious environment can sometimes avoid extinction by rapid evolutionary adaptation. …

The connection between random environments and genetic and phenotypic variability has
been a major focus in the population genetic literature. By providing differential access to the …

Stochastic switching is an example of phenotypic bet hedging, where offspring can express
a phenotype different from that of their parents. Phenotypic switching is well documented in …