The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

The invariant chain (Ii) is a transmembrane protein that associates with the MHC class II
molecules in the endoplasmic reticulum. Expression of Ii in MHC class II-negative CVl cells …

Base excision repair (BER) is initiated by a DNA glycosylase and is completed by alternative
routes, one of which requires proliferating cell nuclear antigen (PCNA) and other proteins …

Double‐stranded RNA (dsRNA) is produced during the replication cycle of most viruses and
triggers antiviral immune responses through Toll‐like receptor 3 (TLR3). However, the …

Class II molecules of the major histocompatibility complex (MHC) bind peptides derived from
protein antigens delivered into endocytic compartments and present these peptides to CD4…

CLASS II histocompatibility molecules associate with peptides derived from antigens that
are processed in endocytic compartments. Antigen presentation to class II-restricted T cells …

Toll-like receptor 4 (TLR4) is indispensable for recognition of Gram-negative bacteria. We
described a trafficking pathway for TLR4 from the endocytic recycling compartment (ERC) to E. …

SorLA/LR11 (250 kDa) is the largest and most composite member of the Vps10p-domain
receptors, a family of type 1 proteins preferentially expressed in neuronal tissue. SorLA binds …

Lipoteichoic acid (LTA) is a central inducer of inflammatory responses caused by Gram-positive
bacteria, such as Staphylococcus aureus, via activation of TLR2. Localization of TLR2 in …

The essentials of the mechanism that targets soluble proteins to lysosomes were described
more than a decade ago t, Soluble lysosomal hydrolases are tagged with mannose 6-…