Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
O Mandelboim, N Lieberman, M Lev, L Paul, TI Arnon… - Nature, 2001 - nature.com
Natural killer (NK) cells destroy virus-infected and tumour cells, apparently without the need
for previous antigen stimulation 1 . In part, target cells are recognized by their diminished …
for previous antigen stimulation 1 . In part, target cells are recognized by their diminished …
[HTML][HTML] Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression
Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human
colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, …
colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, …
Activating natural cytotoxicity receptors of natural killer cells in cancer and infection
J Koch, A Steinle, C Watzl, O Mandelboim - Trends in immunology, 2013 - cell.com
Natural killer (NK) cells are central players in the vertebrate immune system that rapidly
eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) …
eliminate malignantly transformed or infected cells. The natural cytotoxicity receptors (NCRs) …
The unique properties of uterine NK cells
I Manaster, O Mandelboim - American journal of reproductive …, 2010 - Wiley Online Library
… However, we have recently found that freshly isolated peripheral blood NK cells also
express CD9 (Manaster I, Mandelboim O, unpublished data) and therefore we claim that CD9 …
express CD9 (Manaster I, Mandelboim O, unpublished data) and therefore we claim that CD9 …
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
…, A Porgador, E Keshet, S Yagel, O Mandelboim - Nature medicine, 2006 - nature.com
Human CD56 bright NK cells accumulate in the maternal decidua during pregnancy and are
found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to …
found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to …
Tumor and viral recognition by natural killer cells receptors
TI Arnon, G Markel, O Mandelboim - Seminars in cancer biology, 2006 - Elsevier
Natural killer (NK) cells destroy hazardous cells such as tumors and virus-infected cells
immediately without the need for prior antigen stimulation. The activation of NK cells largely …
immediately without the need for prior antigen stimulation. The activation of NK cells largely …
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D
…, N Stanietsky, M Mandelboim, O Mandelboim - Nature …, 2008 - nature.com
MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A
microRNA encoded by human cytomegalovirus downregulates MICB expression by …
microRNA encoded by human cytomegalovirus downregulates MICB expression by …
[PDF][PDF] Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack
…, CA Brennan, WS Garrett, G Bachrach, O Mandelboim - Immunity, 2015 - cell.com
Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment.
However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we …
However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we …
[PDF][PDF] Trained memory of human uterine NK cells enhances their function in subsequent pregnancies
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast invasion
and angiogenesis. Several diseases of poor placental development are associated with …
and angiogenesis. Several diseases of poor placental development are associated with …
[PDF][PDF] Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
…, K Thiam, N Cerf-Bensussan, O Mandelboim… - Immunity, 2008 - cell.com
Natural killer (NK) cells are innate lymphocytes with spontaneous antitumor activity, and they
produce interferon-γ (IFN-γ) that primes immune responses. Whereas T helper cell subsets …
produce interferon-γ (IFN-γ) that primes immune responses. Whereas T helper cell subsets …