Chemical strategies to using small molecules to stimulate hypoxia inducible factors (HIFs)
activity and trigger a hypoxic response under normoxic conditions, such as iron chelators and …

Background The purpose of this study was to determine the changes in the plasma
concentration of rocuronium and the reversal of its neuromuscular blockade after the intravenous …

Widespread resistance to first-line TB drugs is a major problem that will likely only be resolved
through the development of new drugs with novel mechanisms of action. We have used …

The von Hippel–Lindau tumor suppressor protein is the substrate binding subunit of the
VHL E3 ubiquitin ligase, which targets hydroxylated α subunit of hypoxia inducible factors (HIFs) …

Introduction. Glycine is one of the major inhibitory neurotransmitters in the spinal cord and
brain stem of vertebrates. 1 The inhibitory actions of glycine are mediated by the strychnine-…

A potent, noncytotoxic indazole sulfonamide was identified by high-throughput screening of
>100,000 synthetic compounds for activity against Mycobacterium tuberculosis (Mtb). This …

Mycobacterium tuberculosis (MTb) possesses two nonproton pumping type II NADH
dehydrogenase (NDH-2) enzymes which are predicted to be jointly essential for respiratory …

With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis there is a
pressing need for new oral drugs with novel mechanisms of action. Herein, we describe the …

With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent
need for new drugs. Ideally, new agents should work through novel targets so that they are …

Tuberculosis is a major global cause of both mortality and financial burden mainly in low and
middle-income countries. Given the significant and ongoing rise of drug-resistant strains of …