Attainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant
mitochondria and increased energy expenditure potential, is a legitimate strategy for combating …

mRNA translation plays a central role in the regulation of gene expression and represents the
most energy consuming process in mammalian cells. Accordingly, dysregulation of mRNA …

Polysome-profiling is commonly used to study translatomes and applies laborious extraction
of efficiently translated mRNA (associated with >3 ribosomes) from a large volume across …

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

Antisense peptide nucleic acids (PNAs) can specifically inhibit Escherichia coli gene
expression and growth and hold promise as anti-infective agents and as tools for microbial …

The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogen and nutrient
signals to control cell proliferation and cell size. Hence, mTORC1 is implicated in a large …

mRNA translation is thought to be the most energy-consuming process in the cell. Translation
and energy metabolism are dysregulated in a variety of diseases including cancer, …

Translational regulation plays a critical role in the control of cell growth and proliferation. A
key player in translational control is eIF4E, the mRNA 5′ cap-binding protein. Aberrant …

Protein synthesis is one of the most energy consuming processes in the cell. The
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that integrates a …

The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism
remain poorly understood. Here, we show that exposure of mice to cold led to activation of …