The astrocytic cystine/glutamate antiporter system x c − represents an important source of
extracellular glutamate in the central nervous system, with potential impact on excitatory …

The cystine/glutamate antiporter system x c − has been identified as the major source of
extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, …

Acinar cell dedifferentiation is one of the most notable features of acute and chronic
pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the …

Background Treatments for pancreatic ductal adenocarcinoma are poorly effective, at least
partly due to the tumor’s immune-suppressive stromal compartment. New evidence of …

Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases
and has been frequently correlated with the altered expression and/or function of astrocytic …

xCT (Slc7a11), the specific subunit of the cystine/glutamate antiporter, is present in the brain
and on immune cells, where it is known to modulate behavior and inflammatory responses. …

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate
antiporter system x c − in neurological disorders and in cancer, none of the proposed inhibitors …

Background. Population ageing challenges health care systems due to the high prevalence
and impact of multimorbidity in older adults. However, little is known about how chronic …

Purpose Loneliness and depression are associated, in particular in older adults. Less is
known about the role of social networks in this relationship. The present study analyzes the …

Objective This study aimed to examine the association of loneliness and social isolation on
cognition over a 3‐year follow‐up period in middle‐ and older‐aged adults. Methods Data …