Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity to …

High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare
but have a very poor prognosis and represent a severely understudied class of tumours. …

Adaptor/scaffold proteins serve as platforms for the assembly of multiprotein complexes and
regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an …

The critical point for successful treatment of cancer is diagnosis at early stages of tumor
development. Cancer cell-specific methylated DNA has been found in the blood of cancer …

Importance About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade
serous ovarian cancers (HGSOCs) harborBRCA1promoter methylation. While …

Background Normal cell BRCA1 epimutations have been associated with increased risk of
triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 …

Pre-mRNA structure impacts many cellular processes, including splicing in genes associated
with disease. The contemporary paradigm of RNA structure prediction is biased toward …

Activity‐regulated cytoskeleton‐associated protein (Arc) is a protein interaction hub with
diverse roles in intracellular neuronal signaling, and important functions in neuronal synaptic …

Activity-regulated cytoskeletal-associated protein (Arc) is implicated as a master regulator of
long-term synaptic plasticity and memory formation in mammalian brain. Arc acts at …

The selective and neuronal activity-dependent degradation of synaptic proteins appears to
be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-…