Importance Pediatric cancers are epigenetic diseases; therefore, considering tumor gene
expression information is necessary for a complete understanding of the tumorigenic processes…

Accelerating cures for children with cancer remains an immediate challenge as a result of
extensive oncogenic heterogeneity between and within histologies, distinct molecular …

Purpose Somatic variants in tumor necrosis factor receptor–associated factor 7 (TRAF7) cause
meningioma, while germline variants have recently been identified in seven patients with …

Overcoming replicative senescence is an essential step during oncogenesis, and the
reactivation of TERT through promoter mutations is a common mechanism. TERT promoter …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Pediatric brain tumors are the leading cause of cancer-related death in children in the United
States and contribute a disproportionate number of potential years of life lost compared to …

Diffuse midline gliomas (DMGs) bearing driver mutations of histone 3 lysine 27 (H3K27M)
are incurable brain tumors with unique epigenomes. Here, we generated a syngeneic …

Although increasingly recognized as critical to genomic research, genomic data sharing is
hindered by an absence of standards regarding timing, patient privacy, use agreement …

Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by
germline mutations in TP53. TP53 is the most common mutated gene in human cancer, …

Cancer cell lines have been widely used for decades to study biological processes driving
cancer development, and to identify biomarkers of response to therapeutic agents. Advances …