[HTML][HTML] TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
Background In multiple sclerosis, inflammation can successfully be prevented, while promoting
repair is still a major challenge. Microglial cells, the resident phagocytes of the central …
repair is still a major challenge. Microglial cells, the resident phagocytes of the central …
A TSPO ligand is protective in a mouse model of multiple sclerosis
DJ Daugherty, V Selvaraj, OV Chechneva… - EMBO molecular …, 2013 - embopress.org
Local production of neurosteroids such as progesterone and allopregnanolone confers
neuroprotection in central nervous system (CNS) inflammatory diseases. The mitochondrial …
neuroprotection in central nervous system (CNS) inflammatory diseases. The mitochondrial …
[HTML][HTML] hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
Human pluripotent stem cells (hPSCs) have been differentiated to astroglia, but the utilization
of hPSC-derived astroglia as cell therapy for neurological diseases has not been well …
of hPSC-derived astroglia as cell therapy for neurological diseases has not been well …
[HTML][HTML] Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional …
…, S Biswas, J Li, CJ Mao, O Chechneva… - Translational …, 2020 - Springer
Background Parkinson’s disease (PD) is one of the neurodegeneration diseases characterized
by the gradual loss of dopaminergic (DA) neurons in the substantia nigra region of the …
by the gradual loss of dopaminergic (DA) neurons in the substantia nigra region of the …
[HTML][HTML] p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes
In CNS lesions, “reactive astrocytes” form a prominent cellular response. However, the nature
of this astrocyte immune activity is not well understood. In order to study astrocytic immune …
of this astrocyte immune activity is not well understood. In order to study astrocytic immune …
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain
…, AM Soulika, W Deng, OV Chechneva - Journal of Experimental …, 2023 - rupress.org
Material transfer is an essential form of intercellular communication to exchange information
and resources between cells. Material transfer between neurons and from glia to neurons …
and resources between cells. Material transfer between neurons and from glia to neurons …
Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration …
OV Chechneva, F Mayrhofer, DJ Daugherty… - Neurobiology of …, 2011 - Elsevier
Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of
cough medicine. Relatively high doses of DM in combination with quinidine are used for the …
cough medicine. Relatively high doses of DM in combination with quinidine are used for the …
[PDF][PDF] Differentiating human stem cells into neurons and glial cells for neural repair
1. Abstract 2. Introduction 3. Types of stem cells 3.1. Adult stem cells 3.2. Embryonic stem cells
3.3. Induced pluripotent stem cells 4. Differentiation of stem cells into neural lineages 4.1. …
3.3. Induced pluripotent stem cells 4. Differentiation of stem cells into neural lineages 4.1. …
[HTML][HTML] Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro
…, H Wen, F Mayrhofer, O Chechneva… - Stem cell research & …, 2019 - Springer
Background Oligodendrocytes are a type of glial cells that synthesize the myelin sheath
around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death …
around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death …
[HTML][HTML] The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis
DJ Daugherty, O Chechneva, F Mayrhofer, W Deng - Scientific reports, 2016 - nature.com
The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here,
we sought to determine the specific role of TSPO in experimental autoimmune …
we sought to determine the specific role of TSPO in experimental autoimmune …