Bacterial infection remains a serious threat to human lives because of emerging resistance
to existing antibiotics. Although the scientific community has avidly pursued the discovery of …

Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused
by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to …

Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

Emergence of bacterial resistance is a major issue for all classes of antibiotics; therefore,
the identification of new classes is critically needed. Recently we reported the discovery of …

For decades, microbial natural products have been one of the major sources of novel drugs
for pharmaceutical companies, and today all evidence suggests that novel molecules with …

Fatty acids are essential for survival of bacteria and are synthesized by a series of enzymes
including the elongation enzymes, β-ketoacyl acyl carrier protein synthase I/II (FabF/B). …

Actinomycetes, one of the major communities of the microbial population present in soil, can
also be found inhabiting a wide diversity of ecological sources. We have explored the use of …

The discovery of antibiotics for the treatment of bacterial infections has been one of the most
important medical achievements of the past 60 years.[1] However, the emergence of …

Bacterial resistance to known therapeutics has led to an urgent need for new chemical classes
of antibacterial agents. To address this we have applied a Staphylococcus aureus fitness …