Leptin resistance: underlying mechanisms and diagnosis

O Gruzdeva, D Borodkina, E Uchasova… - … syndrome and obesity …, 2019 - Taylor & Francis
Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and …

[HTML][HTML] Localization of fat depots and cardiovascular risk

O Gruzdeva, D Borodkina, E Uchasova… - Lipids in health and …, 2018 - Springer
Despite the existing preventative and therapeutic measures, cardiovascular diseases remain
the main cause of temporary disability, long-term disability, and mortality. Obesity is a major …

[HTML][HTML] Relationship between epicardial and coronary adipose tissue and the expression of adiponectin, leptin, and interleukin 6 in patients with coronary artery …

OV Gruzdeva, YA Dyleva, EV Belik, MY Sinitsky… - Journal of Personalized …, 2022 - mdpi.com
Adipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active
adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and …

[HTML][HTML] Relationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarction

O Gruzdeva, E Uchasova, Y Dyleva… - Cardiovascular …, 2018 - Springer
Background Determination of the impact of visceral obesity and epicardial adipose tissue
thickness on stimulating growth factor levels during hospitalization for myocardial infarction is …

[HTML][HTML] Glucose levels as a prognostic marker in patients with ST-segment elevation myocardial infarction: a case–control study

V Karetnikova, O Gruzdeva, E Uchasova… - BMC Endocrine …, 2016 - Springer
Background Patients with myocardial infarction (MI) have a high mortality. Therefore, new
risk markers and predictors of an adverse outcome for MI are required. The role of …

[HTML][HTML] Adipocytes directly affect coronary artery disease pathogenesis via induction of adipokine and cytokine imbalances

O Gruzdeva, E Uchasova, Y Dyleva… - Frontiers in …, 2019 - frontiersin.org
This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial
and subcutaneous adipose tissues in interconnection with the visceral adipose tissue …

[HTML][HTML] Calciprotein particles link disturbed mineral homeostasis with cardiovascular disease by causing endothelial dysfunction and vascular inflammation

…, AE Kostyunin, AV Tsepokina, OV Gruzdeva… - International journal of …, 2021 - mdpi.com
An association between high serum calcium/phosphate and cardiovascular events or death
is well-established. However, a mechanistic explanation of this correlation is lacking. Here, …

[HTML][HTML] Lipid, adipokine and ghrelin levels in myocardial infarction patients with insulin resistance

O Gruzdeva, E Uchasova, E Belik, Y Dyleva… - BMC cardiovascular …, 2014 - Springer
Background Insulin resistance (IR) is a risk factor for ischaemic heart disease and myocardial
infarction (MI). IR often manifests in MI and is regarded as an independent predictor of in-…

[HTML][HTML] Multivessel coronary artery disease, free fatty acids, oxidized LDL and its antibody in myocardial infarction

O Gruzdeva, E Uchasova, Y Dyleva, E Belik… - Lipids in health and …, 2014 - Springer
Background Free fatty acids (FFA), oxidized low-density lipoprotein (LDL) and its antibodies,
lipid profile markers, which are formed under oxidative stress, play an important role in …

[HTML][HTML] Prognostic value of soluble ST2 during hospitalization for ST-segment elevation myocardial infarction

O Barbarash, O Gruzdeva, E Uchasova… - Annals of laboratory …, 2016 - ncbi.nlm.nih.gov
Background Studying the role of soluble ST2 (sST2) during hospitalization for myocardial
infarction (MI) can be helpful for predicting the course of the hospitalization and development …