User profiles for Olga Gursky
 | olga gurskyProfessor of Physiology and Biophysics, Boston University School of Medicine Verified email at bu.edu Cited by 3340 |
Monitoring protein aggregation during thermal unfolding in circular dichroism experiments
S Benjwal, S Verma, KH Röhm, O Gursky - Protein Science, 2006 - Wiley Online Library
Thermal unfolding monitored by spectroscopy or calorimetry is widely used to determine
protein stability. Equilibrium thermodynamic analysis of such unfolding is often hampered by its …
protein stability. Equilibrium thermodynamic analysis of such unfolding is often hampered by its …
Thermal unfolding of human high-density apolipoprotein A-1: implications for a lipid-free molten globular state.
O Gursky, D Atkinson - … of the National Academy of Sciences, 1996 - National Acad Sciences
Apolipoprotein A-1 (apoA-1) in complex with high-density lipoprotein is critically involved in
the transport and metabolism of cholesterol and in the pathogenesis of atherosclerosis. We …
the transport and metabolism of cholesterol and in the pathogenesis of atherosclerosis. We …
[HTML][HTML] Temperature-dependent β-sheet formation in β-amyloid Aβ1–40 peptide in water: uncoupling β-structure folding from aggregation
O Gursky, S Aleshkov - Biochimica et Biophysica Acta (BBA)-Protein …, 2000 - Elsevier
To probe the role of temperature in the conversion of soluble Alzheimer’s β-amyloid peptide
(Aβ) to insoluble β-sheet rich aggregates, we analyzed the solution conformation of Aβ 1–40 …
(Aβ) to insoluble β-sheet rich aggregates, we analyzed the solution conformation of Aβ 1–40 …
Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights
Apolipoproteins are protein constituents of lipoproteins that transport cholesterol and fat in
circulation and are central to cardiovascular health and disease. Soluble apolipoproteins can …
circulation and are central to cardiovascular health and disease. Soluble apolipoproteins can …
The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain
ES Klimtchuk, O Gursky, RS Patel, KL Laporte… - Biochemistry, 2010 - ACS Publications
Light chain (LC) amyloidosis (AL) is a fatal disease in which immunoglobulin LC deposit as
fibrils. Although the LC amyloid-forming propensity is attributed primarily to the variable …
fibrils. Although the LC amyloid-forming propensity is attributed primarily to the variable …
The crystal structure of the C-terminal truncated apolipoprotein AI sheds new light on amyloid formation by the N-terminal fragment
O Gursky, X Mei, D Atkinson - Biochemistry, 2012 - ACS Publications
Apolipoprotein AI (apoA-I) is the main protein of plasma high-density lipoproteins (HDL, or
good cholesterol) that remove excess cell cholesterol and protect against atherosclerosis. In …
good cholesterol) that remove excess cell cholesterol and protect against atherosclerosis. In …
Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis
…, DL Gantz, C Haupt, O Gursky - Proceedings of the …, 2017 - National Acad Sciences
Serum amyloid A (SAA) is an acute-phase plasma protein that functions in innate immunity
and lipid homeostasis. SAA is a protein precursor of reactive AA amyloidosis, the major …
and lipid homeostasis. SAA is a protein precursor of reactive AA amyloidosis, the major …
[HTML][HTML] Aggregation and fusion of low-density lipoproteins in vivo and in vitro
M Lu, O Gursky - Biomolecular concepts, 2013 - degruyter.com
Low-density lipoproteins (LDLs, also known as ‘bad cholesterol’) are the major carriers of
circulating cholesterol and the main causative risk factor of atherosclerosis. Plasma LDLs are …
circulating cholesterol and the main causative risk factor of atherosclerosis. Plasma LDLs are …
Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks
NM Frame, O Gursky - FEBS letters, 2016 - Wiley Online Library
Serum amyloid A is a major acute‐phase plasma protein that modulates innate immunity
and cholesterol homeostasis. We combine sequence analysis with x‐ray crystal structures to …
and cholesterol homeostasis. We combine sequence analysis with x‐ray crystal structures to …
Amyloidogenic mutations in human apolipoprotein A‐I are not necessarily destabilizing–a common mechanism of apolipoprotein A‐I misfolding in familial amyloidosis …
…, X Mei, S Jayaraman, D Atkinson, O Gursky - The FEBS …, 2014 - Wiley Online Library
High‐density lipoproteins and their major protein, apolipoprotein A‐I (apoA‐I), remove excess
cellular cholesterol and protect against atherosclerosis. However, in acquired amyloidosis…
cellular cholesterol and protect against atherosclerosis. However, in acquired amyloidosis…