10.7554/eLife.38319.001 Calcium (Ca 2+ ) dysregulation is a hallmark of heart failure and is
characterized by impaired Ca 2+ sequestration into the sarcoplasmic reticulum (SR) by the …

Telomeres protect DNA ends of linear eukaryotic chromosomes from degradation and fusion,
and ensure complete replication of the terminal DNA through recruitment of telomerase. …

The conformational changes of a calcium transport ATPase were investigated with
molecular dynamics (MD) simulations as well as fluorescence resonance energy transfer (FRET) …

Multidrug resistance protein 1 (MRP1) actively transports a wide variety of drugs out of cells.
To quantify MRP1 structural dynamics, we engineered a “two-color MRP1” construct by …

… Closure is accompanied by functional interactions between the N-domain b5–b6 loop and
the Adomain … Olga N. Raguimova and Rodrigo Aguayo-Ortiz contributed equally to this work. …

Evolutionarily conserved shelterin complex is essential for telomere maintenance in the
fission yeast Schizosaccharomyces pombe. Elimination of the fission yeast shelterin subunit …

The sarco/endoplasmic reticulum calcium ATPase (SERCA) is the major regulator of Ca 2+
levels in the cell. Deficient calcium handling in the heart has been linked to heart failure, a …

Sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA) and phospholamban (PLB) are
essential for intracellular Ca 2+ transport in myocytes. Ca 2+ -dependent activation of SERCA–…

The cardiac sarco/endoplasmic reticulum (SR) calcium ATPase (SERCA) and its inhibitor
phospholamban (PLB) are key regulators of calcium levels in cardiac cells. SERCA contributes …

The cardiac sarco/endoplasmic reticulum (ER) calcium ATPase (SERCA) and its inhibitor
phospholamban (PLB) are key regulators of calcium levels in cardiac cells. In previous …