A large response range can be observed in both behavioral and neuroendocrine responses
to environmental challenges. This variation can arise from central mechanisms such as …

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by different
patterns of airway remodeling, which all include an increased mass of bronchial smooth …

Human airway smooth muscle cells (HASMC) secrete fractalkine (FKN), a chemokine the
concentration of which is increased in asthmatic patients. HASMC also induce mast cell …

Asthmatic patients have higher numbers of mast cells in the smooth muscle layer of airways
than normal subjects. Human airway smooth muscle cells (HASMCs) are a source of various …

Rationale: Bronchial remodeling, including increased bronchial smooth muscle (BSM) mass,
contributes to bronchial obstruction in asthma. However, its mechanisms are complex and …

Rationale: Asthma is a frequent airway disease, and asthma control determinants have been
associated with indoor allergen sensitization. The most frequent allergens are house dust …

We present data suggesting that corticosteroid-binding globulin (CBG) may be the causal
gene of a previously identified quantitative trait locus (QTL) associated with cortisol levels, fat, …

Background Chronic obstructive pulmonary disease (COPD) is characterized by peribronchial
fibrosis. The chronic course of COPD is worsened by recurrent acute exacerbations. …

Rhinovirus (RV) infection of the bronchial epithelium is implicated in the vast majority of
severe asthma exacerbations. Interestingly, the susceptibility of bronchial epithelium to RV …

Rationale: Increased bronchial smooth muscle (BSM) mass is a key feature of airway remodeling
that classically distinguishes severe from nonsevere asthma. Proliferation of BSM cells …