Higher order chromatin structure presents a barrier to the recognition and repair of DNA
damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is …

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing
γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to …

Sedelnikova, OA, Rogakou, EP, Panyutin, IG and Bonner, WM Quantitative Detection of 125
IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody. Radiat. Res. 158, 486–492 (…

Humans and animals undergo ageing, and although their primary cells undergo cellular
senescence in culture, the relationship between these two processes is unclear 1 , 2 . Here we …

Histone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-strand
breakage associated with γ-irradiation, meiotic recombination, DNA replication, and …

DNA double-strand breaks originating from diverse causes in eukaryotic cells are accompanied
by the formation of phosphorylated H2AX (γH2AX) foci. Here we show that γH2AX …

Genome stability is essential for maintaining cellular and organismal homeostasis, but it is
subject to many threats. One ubiquitous threat is from a class of compounds known as …

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant,
H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed γ-H2AX, is …

DNA double strand fission, like its atomic counterpart, is useful when controlled but potentially
lethal when not. On the useful side, the programmed DNA double strand break (DSB) is …

Ionizing radiation (IR) exposure is inevitable in our modern society and can lead to a variety
of deleterious effects including cancer and birth defects. A reliable, reproducible and …