In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome
packaging inherently restricts DNA accessibility for regulatory proteins but also provides an …

Posttranslational histone modifications are important for gene regulation, yet the mode of
propagation and the contribution to heritable gene expression states remains controversial. To …

Cellular differentiation involves profound remodelling of chromatic landscapes, yet the
mechanisms by which somatic cell identity is subsequently maintained remain incompletely …

Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-onset
neurodegeneration by an unknown mechanism. We report that young adult Irp2 -/- mice …

Deposition of variant histones provides a mechanism to reset and to potentially specify
chromatin states. We determined the distribution of H3 and its variant H3.3 relative to chromatin …

Post‐translational modifications of histones are involved in transcript initiation and elongation.
Methylation of lysine 36 of histone H3 (H3K36me) resides promoter distal at transcribed …

Duplication of eukaryotic genomes during S phase is coordinated in space and time. In
order to identify zones of initiation and cell-type- as well as gender-specific plasticity of DNA …

Purpose Foods rich in antioxidant and anti-inflammatory phytochemicals might attenuate
skeletal muscle damage; thus, the present study investigated whether consuming an …

Heterochromatin is a key characteristic of eukaryotic genomes. Since its cytological description
nearly 100 years ago, our understanding of heterochromatin features and functions, …

Histone modifications are thought to regulate gene expression in part by modulating DNA
accessibility. Here, we measured genome-wide DNA accessibility in Drosophila melanogaster …