Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential
to provide improved cellular models of human disease. However, variable genetic and …

B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repressor that
regulates cell growth and differentiation in multiple tissues, including skin. Although in the …

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a
potentially powerful tool for investigating the relationship between genetic variants and cellular …

The 12 genome-wide association studies (GWAS) published to-date for late-onset Alzheimer’s
disease (LOAD) have identified over 40 candidate LOAD risk modifiers, in addition to …

Induced pluripotent stem cells (iPSCs) provide invaluable opportunities for future cell
therapies as well as for studying human development, modelling diseases and discovering …

Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular
deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, …

Although human dermis contains distinct fibroblast subpopulations, the functional
heterogeneity of fibroblast lines from different donors is under-appreciated. We identified one …

Self-renewing stem cell populations are increasingly considered as resources for cell
therapy and tools for drug discovery. Human pluripotent stem (hPS) cells in particular offer a …

GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association
signal for late-onset Alzheimer’s disease (LOAD) with reported odds ratios (ORs) ranging …

Large cohorts of human iPSCs from healthy donors are potentially a powerful tool for investigating
the relationship between genetic variants and cellular phenotypes. Here we integrate …