We developed a new, simple and robust approach for rapid screening of single molecule
interactions with protein channels. Our glass nanopipets can be fabricated simply by drawing …

Current virus detection methods often take significant time or can be limited in sensitivity and
specificity. The increasing frequency and magnitude of viral outbreaks in recent decades …

Genomes are constantly in flux, undergoing changes due to recombination, repair and
mutagenesis. In vivo, many of such changes are studies using reporters for specific types of …

Bacterial transcription by RNA polymerase (RNAP) is spatially organized. RNAPs transcribing
highly expressed genes locate in the nucleoid periphery, and form clusters in rich medium…

… Oliver J. Pambos thanks the EPRSC for funding through the Physics of Medicine Initiative,
University of Cambridge. Kerstin Göpfrich acknowledges Dr. Klaus Mecke from Friedrich-…

Although materials with structural colours are known to be resistant to photobleaching, the
damage caused by structural failure and lack of suitable fabrication methods limit their …

During transcription elongation, NusG aids RNA polymerase by inhibiting pausing, promoting
anti-termination on rRNA operons, coupling transcription with translation on mRNA genes, …

This month's Under the Lens discusses the use of single-molecule tracking to study the
effects and response of bacterial cells exposed to antibiotics.

Bacterial transcription by RNA polymerase (RNAP) is spatially organised. RNAPs transcribing
highly expressed genes locate in the nucleoid periphery, and form clusters in rich media, …

Efficient DNA repair is crucial for maintaining genome integrity and ensuring cell survival. In
Escherichia coli, RecBCD plays a crucial role in processing DNA ends following a DNA …