A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis
and developing therapies. Exome-sequencing studies have mapped many protein-…

Somatic mutations in cancer genomes are associated with DNA replication timing (RT) and
chromatin accessibility (CA), however these observations are based on normal tissues and …

Background Regional distribution of somatic mutations in cancer genomes associates with
DNA replication timing (RT) and chromatin accessibility (CA), however normal tissues and …

Somatic mutation rates in cancer genomes are associated with chromatin state and informative
of tumor tissue of origin. However, earlier studies considered the chromatin states of cell …

Cancer genomes are shaped by mutational processes with complex spatial variation at multiple
scales. However, the underlying mechanisms of this mutagenesis and its functional and …

O-GlcNAc transferase (OGT) is an essential glycosylating enzyme that catalyzes the addition
of N-acetylglucosamine to serine or threonine residues of nuclear and cytoplasmic proteins. …

CCCTC-binding factor (CTCF) and the cohesin complex anchor chromatin loops and domains
that regulate genomic interactions and transcription. These elements are also enriched for …

Medulloblastoma is a common paediatric brain tumor, arising within the hindbrain and affecting
approximately 18-20% of children diagnosed with brain cancer. Metastasis is present in …

Local mutation rates in human are highly heterogeneous, with known variability at the scale
of megabase-sized chromosomal domains, and, on the other extreme, at the scale of …

Mutational signatures represent a genomic footprint of endogenous and exogenous mutational
processes through tumor evolution. However, their functional impact on the proteome …