During division of metazoan cells, the nucleus disassembles to allow chromosome segregation,
and then reforms in each daughter cell. Reformation of the nucleus involves chromatin …

Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …

Ubiquitous calpains (μ- and m-calpain) have been repeatedly implicated in apoptosis, but
the underlying mechanism(s) remain(s) to be elucidated. We examined ionomycin-induced …

The Dnmt2 enzyme utilizes the catalytic mechanism of eukaryotic DNA methyltransferases
to methylate several tRNA s at cytosine 38. Dnmt2 mutant mice, flies, and plants were …

Damaged replication forks activate poly(ADP-ribose) polymerase 1 (PARP1), which catalyses
poly(ADP-ribose) (PAR) formation; however, how PARP1 or poly(ADP-ribosyl)ation is …

The immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide are highly effective
treatments for multiple myeloma. However, virtually all patients eventually relapse due to …

Neuroligin-4 (NLGN4) loss-of-function mutations are associated with monogenic heritable
autism spectrum disorder (ASD) and cause alterations in both synaptic and behavioral …

These findings show that YAP cooperates with β-catenin in basal-like breast cancer to
regulate CSCs and that targeting this interaction may be a novel CSC therapy for patients with …

Neutrophils provide a critical line of defense in immune responses to various pathogens,
inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work has …

The Doa10 quality control ubiquitin (Ub) ligase labels proteins with uniform lysine 48-linked
poly-Ub (K48-pUB) chains for proteasomal degradation. Processing of Doa10 substrates …