Dynamic assembly of spatially separated signaling platforms enables a cell to tune cellular
outputs in response to different input stimuli. Understanding how a vast diversity in signaling …

We show that the specific subcellular distribution of H- and Nras guanosine triphosphate–binding
proteins is generated by a constitutive de/reacylation cycle that operates on …

Reversible S-palmitoylation of cysteine residues critically controls transient membrane
tethering of peripheral membrane proteins. Little is known about how the palmitoylation …

Cycles of depalmitoylation and repalmitoylation critically control the steady-state
localization and function of various peripheral membrane proteins, such as Ras proto-oncogene …

Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …

Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …

Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for
dominant, apoptosis-inducing genes. ANT-1 is a component of the mitochondrial …

The epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinase (RTK)
superfamily and is involved in regulating cell proliferation, differentiation and motility 1 . …

Steady-state fluorescence anisotropy measurements can be used to detect fluorescence
resonance energy transfer (FRET) between identical fluorophores (homo-FRET). However, the …

GTPases of immunity-associated proteins (GIMAPs) are regulators of lymphocyte survival
and homeostasis. We previously determined the structural basis of GTP-dependent GIMAP2 …